Reza Hassanzadeh started his football with Esteghlal Tehran where he spent most of his professional career.
in 1993 he transferred to the Al Kuwait club where he played for two seasons. He rejoined Esteghlal in 1995 until the twilight of his career in 2001. Before retirement, he played one season only for Pegah Gilan.
Hassanzadeh played for Team Melli for almost a decade in the 90s. During his professional career, he scored 2 important goals.
The unique record is participating in three finals of the Asian Champions League with Esteghlal Tehran, which is also a record in Asian football. Hassanzadeh has played in 3 finals in 1999, 1992, and 1991.