Queiroz realized his blunder against England and opted to change the shape of the team for the match against Wales in Group B of FIFA World Cup Qatar 2022. In defense, the same poor lineup is maintained though, except for the right back where Ramin Rezaeian is replacing Moharrami. In the midfield, Karimi and Cheshmi are out, replaced by Gholizadeh and Ezatollahi. The biggest surprise was the exclusion of Alireza Jaganbakhsh who had a bad day against England, with Sardar Azmoun.
The line-up is as follows:
| 24 | Hossein Hosseini |
| 8 | Morteza Pouraliganji |
| 23 | Ramin Rezaeian |
| 19 | Majid Hosseini |
| 5 | Milad Mohammadi |
| 3 | Ehsan Hajisafi |
| 21 | Ahmad Noorollahi |
| 6 | Saeid Ezatolahi |
| 17 | Ali Gholizadeh |
| 9 | Mehdi Taremi |
| 20 | Sardar Azmoun |